Endocrine Abstracts

Introduction: Patients with non-functioning pituitary adenomas (NFPA) and hipopituitarism had a reduced life expectancy.Aims: To assess mortality ratio and to identify prognostic factors associated with mortality in patients with NFPA in the last decade.Methods: A 196 patients (83 F/113 M, mean age 52.7±0.9 years) with NFPA admitted in a single Neuroendocrinology Department between January 2001 and December 2010 were retrospec...

Background: A large spectrum of AIP gene mutations has been identified in familial and sporadic pituitary adenomas (PA) with over 70 different mutations described to date. c.47G>A, p.R16H is an AIP exon 1 variant of unknown significance, its contribution to pituitary adenoma development being controversial.Aim: Characterization of p.R16H prevalence in a large Romanian cohort of PA patients and controls.Patients and methods: spo...

The structural and functional effects upon arterial vessels of GH and IGF1, chronically elevated in active acromegaly, are risk factors for premature atherosclerosis, but current therapies can normalize GH and IGF1 production.Aims: To evaluate if carotid wall alterations in acromegaly are reversible after disease control.Material and methods: Fifteen patients with controlled acromegaly (CA) after multimodal therapy (45.5±</...

AbstractThyroid angiosarcoma is an aggressive and very rare type of thyroid malignancy originally diagnosed in iodine-deficient areas. The prognosis is poor and in most cases surgery proved to be inefficient. The fine needle aspiration biopsy (FNAB) and histology can rarely differentiate angiosarcoma from anaplastic carcinoma, and the final diagnosis is based on immunopositivity for vascular markers and absence of epithelial markers. We present he...

Introduction: Phaeochromocytomas (PHEO) are tumours of the chromaffin cells and are usually detected due to the typical symptom triad including headache, palpitations and sweating associated with persistent and/or paroxysmal blood hypertension. An increasing proportion of PHEO is incidentally discovered upon abdominal imaging.Objective: To analyse the clinical characteristics of the incidentally discovered phaeochromocytomas.Method...

BackgroundAcromegaly is a rare disease, caused by an autonomous excessive secretion of growth hormone (GH). Apart from skeletal alterations, the GH excess leads to metabolic and visceral disease. Thus, one of the most frequent associated complications is the cardio-vascular one represented by hypertension, cardiomyopathy and ischemic heart disease. The presence of multiple complications in patients with acromegaly leads not only to increased morbidity an...

Background: Acromegaly is characterized by increased prevalence of fragility vertebral fractures. Nonetheless, there are no clear recommendations for prevention of acromegalic osteopathy. Both bone mineral density (BMD) and trabecular bone score (TBS) lack clear evidence as prognostic factors for vertebral fractures (VF).Material and Methods: We performed an observational study on 31 acromegalic patients recruited prospectively. They were tested for alka...

Introduction: The congenital cystic neck masses underlie various diagnosis including tymic cysts. Even they are an embryological defects, the adult onset might be seen. The aetiology is not clearly established. The malignant behaviour or infections are correlated to the cysts. Aim: we present a female case with a complicated history of cysts.Case report: 42-year old female is known with the following medical history. Seven years ago she was operated for ...

Introduction: Patients with untreated acromegaly have a reduced survival, mostly due to vascular disease. Recent studies claim an improvement of survival in the last years.Aims: To assess mortality ratio and to identify prognostic factors associated with reduced survival in acromegaly.Methods: Three hundred and twenty-seven patients (207 F/110 M, mean age 48.1±0.7 years, (range 18–81.42)) with acromegaly admitted in a sin...

Introduction: We have recently described a novel AIP mutation c.940C>T, p.R314W, in a young sporadic acromegaly patient.Aim: To present a new case of AIP p.R314W mutation and screening results of a Romanian control group for p.R314W.Patients and methods: One sporadic acromegaly patient, investigated by sequencing screening of all six AIP exons, following informed consent, as part of a sporadic pituitary adenoma cohort. 110 cont...